Summary: We sought to characterize cellular composition across the cardiovascular system of the healthy Wistar rat, an important model in preclinical cardiovascular research.We performed single-nucleus RNA sequencing (snRNA-seq) in 78 samples in 10 distinct regions, including the four chambers of the heart, ventricular septum, sinoatrial node, atri
It has been proposed that the history and evolution of scientific ideas may reflect certain aspects of the underlying socio-cognitive frameworks in which science itself is developing.Systematic analyses of the development of scientific knowledge may help us to construct models of the collective dynamics of science.Aiming at scientific rigor, these
Abstract Background Selection of an appropriate host organism is crucial for the economic success of biotechnological processes.A generally important selection criterion is a low maintenance energy metabolism to reduce non-productive consumption of substrate.We here investigated, whether various bacilli that are closely related to Bacillus subtilis
Abstract Capillary blood vessels, the smallest vessels in the body, form an intricate network with constantly bifurcating, merging and winding vessels.Red blood cells (RBCs) must navigate through such complex microvascular networks in order to maintain tissue perfusion and oxygenation.Normal, healthy RBCs are extremely deformable and able to easily